Dr. Jiaxu Li
Assistant Professor of Biochemistry and Molecular Biology
Education:
Shenyang Normal
University, B.S. in Biology, 1986.
Hebei Normal
University, M.S. in Biochemistry, 1989.
Pennsylvania State
University, Ph.D. in Plant Physiology, 1998.
Pennsylvania State
University, Post-doctoral Scholar, 08/1998-04/2001.
Harvard Medical
School, Post-doctoral Fellow, 05/2001-08/2003.
Areas of Research:
A fundamental problem in biology is how cells sense and respond to stimuli. Precise sensing and proper responding to environmental changes are of particular importance for plants' survival, because plants are constantly exposed to highly variable conditions (i.e. temperature, light, water status and nutrient) and they cannot move to escape unfavorable or stressful environment. A better understanding of the mechanism of how plant cells sense and respond to environmental stimuli could lead to new strategies for improving stress tolerance of crop plants. We wish to understand aspects of signal processing and transduction pathways in dehydration stress induced by high salt, drought. The plant hormone, abscisic acid (ABA), is involved in regulation of some stress responses. We are particularly interested in molecular elucidation of regulatory protein components critical in ABA-controlled stress responses using proteomics and genomics approaches.
Selected Publications
Ho, H.Y., Rohatgi, R., Lebensohn, A.M., Ma, L., Li J, Gygi, S.P., and Kirschner, M.W. (2004). Toca-1 Mediates Cdc42-Dependent Actin Nucleation by Activating the N-WASP-WIP Complex. Cell 118:203-216.
Gautreau, A., Ho, H., Li, J., Steen, H., Gygi, S.P., and Kirschner, M.W. (2004). Purification and architecture of the ubiquitous Wave Complex. Proc Natl Acad Sci USA 101:4379-4383.
Beausoleil, S.A., Jedrychowski, M., Schwartz, D., Elias, J.E., Villen, J., Li, J., Cohn, M.A., Cantley, L.C., and Gygi, S.P. (2004). Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A 101:12130-12135.
Li, J., Steen H., and Gygi, S.P. (2003). Protein profiling with cleavable isotope coded affinity tag (cICAT) reagents: the yeast salinity stress response. Molecular and Cellular Proteomics 2:1198-1204.
Li, J., Kinoshita, T., Pandey, S., Ng, C. K., Gygi, S.P., Shimazaki, K., and Assmann, S. M. (2002). Modulation of an RNA-binding protein by abscisic-acid-activated protein kinase. Nature 418: 793-797.
Li, J., Moazed, D., and Gygi, S.P. (2002). Association of the histone methytransferase Set2 with RNA polymerase II regulates transcription elongation. Journal of Biological Chemistry 277: 49383-49388.
Li, J., Wang, X.-Q., Watson, M. B., and Assmann, S. M. (2000). Regulation of abscisic acid-induced stomatal closure and anion channels by guard cell AAPK kinase. Science 287: 300-303.
Li, J. and Assmann, S. M. (2000). Mass spectrometry: An essential tool in proteome analysis. Plant Physiology 123: 807-809.
Li, J., Lee, Y.-R., and Assmann, S. M. (1998). Guard cells possess a calcium-dependent protein kinase that phosphorylates the KAT1 K+ channel. Plant Physiology 116: 785-795.
Li, J., and Assmann, S. M. (1996). An abscisic acid-activated and calcium-independent protein kinase from guard cells of fava bean. Plant Cell 8: 2359-2368.
Communication Links
Phone: (662) 325-1115
Fax: (662) 325-8664
Internet:
JL305@Ra.MsState.edu
