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Dwayne A. Wise Education Contact Information |
Statement of Research Interests
The aim of my research is to understand chromosome structure and behavior, especially in living cells. This includes the mechanism of chromosome movement, ways in which chromosome structure and behavior may be approached experimentally and the analysis of meiosis in organisms with unusual modes of chromosome distribution. My recent work centers on the induction of mitosis with unreplicated genomes (MUG) in Chinese hamster ovary and CHO- human hybrid cells. These cells undergo mitosis without chromosomes and provide an opportunity to study kinetochore function in the absence of chromosomes. We are using these cells to analyze nondisjunction of various human kinetochores.
Recent Publications
Johnson, M.K., A.M. Cooksey and D. Wise. 2008. Localization of spindle checkpoint proteins in cells undergoing mitosis with unreplicated genomes. Cell Motility & the Cytoskeleton. 65:890-895. reprint
Herron, W. B., S. M. Lluesma, P. Arana and D. Wise. 2004. Alteration of the metaphase checkpoint by B chromosomes. Cytogen. Genome Res. 107:22- 27
Wilson, Paula J., Arthur Forer and Dwayne Wise. 2003. Microtubule distribution during meiosis in the flea beetle [Alagoasa (Oedionychus)] spermatocytes: evidence for direct connections between unpaired sex chromosomes. J. Cell Sci. 116: 1235-1247.
Green- Marroquin, B. L., H. Kupfer, N. Virkki, and D. A. Wise. 2001. Orientation of nonrandomly segregating sex chromosomes in spermatocytes of the flea beetle, Alagoasa bicolor L. Chromosoma 110: 32- 38.