Dwayne A. Wise
		Professor
		Education B.A. Biology, David Lipscomb College (cum laude) M.A. Genetics, Florida State University Ph.D. Genetics, Florida State University
				Contact Information
		Statement of Research Interests		300 Harned Hall 662.325.7579 662.325.7939 Fax daw1@ra.msstate.edu Lab Web Page
		The aim of my research is to understand chromosome structure and behavior, especially in living cells. This includes the mechanism of chromosome movement, ways in which chromosome structure and behavior may be approached experimentally and the analysis of meiosis in organisms with unusual modes of chromosome distribution. My recent work centers on the induction of mitosis with unreplicated genomes (MUG) in Chinese hamster ovary and CHO- human hybrid cells.  These cells undergo mitosis without chromosomes and provide an opportunity to study kinetochore function in the absence of chromosomes.  We are using these cells to analyze nondisjunction of various human kinetochores.
		Selected Publications
		Herron, W. B., S. M. Lluesma, P. Arana and D. Wise. 2004. Alteration of the metaphase checkpoint by B chromosomes. Cytogen. Genome Res. 107:22- 27
		Wilson, Paula J., Arthur Forer and Dwayne Wise. 2003. Microtubule distribution during meiosis in the flea beetle [Alagoasa (Oedionychus)] spermatocytes: evidence for direct connections between unpaired sex chromosomes. J. Cell Sci. 116: 1235-1247.
		Green- Marroquin, B. L., H. Kupfer, N. Virkki, and D. A. Wise.  2001.  Orientation of nonrandomly segregating sex chromosomes in spermatocytes of the flea beetle, Alagoasa bicolor L.  Chromosoma 110: 32- 38.
		Kupfer, Holly and Dwayne Wise.  2000.  Behavior of sex chromosomes, autosomes and the spindle during nonrandom segregation in a flea beetle.  Genome 43: 521- 527.
Department of Biological Sciences, Mississippi State University, 130 Harned Hall, Lee Blvd., Mississippi State, MS 39762