Edwin A. Lewis

Professor of Chemistry
Department Head

 
Edwin A. Lewis Edwin Lewis came to MSU as Head of the Chemistry Department in 2008. He has held prior academic appointments at Northern Arizona, Brigham Young University and the University of Alabama. Dr. Lewis has also spent time in industry as Executive Vice President and CSO for the Calorimetry Sciences Corporation and the Energetic Genomics Corporation.
email:
telephone: (662) 325-3584
 

Research Summary:

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Publications 2003 - 2008

  1. Lewis, E.A., Murphy, K.P. (2005) "Isothermal Titration Calorimetry", Methods in Molecular Biology , vol 305: Protein-Ligand Interactions: Methods & Applications, Humana Press, Inc, Totowa, NJ,  1-16
  2. Freyer, M.W., Buscaglia, R., Nguyen, B., Wilson, W.D., Lewis, E.A. (2006) "Binding of Netropsin and DAPI to an A2T2 DNA Hairpin: A Comparison of Biophysical Techniques", Analytical Biochemistry, 355, 259-266.
  3. Freyer, M.W., Buscaglia, R., Cashman, D., Hyslop, S., Wilson, W.D., Chaires, J.B., Lewis, E.A. (2007) "Binding of Netropsin to Several DNA Constructs: Evidence for at Least Two Different 1:1 Complexes Formed from an -A2T2- Containing ds-DNA Construct and a Single Minor Groove Binding Ligand", Biophysical Chemistry, 126, 186-196.
  4. Freyer, M.W., Buscaglia, R., Kaplan, K., Cashman, D., Hurley L.H., Lewis E.A., (2007) "Biophysical Studies of the c-MYC NHE III1 Promoter: Model Quadruplex Interactions with a Cationic Porphyrin", Biophysical Journal, 92 (6), 1-9.
  5. Freyer, M.W., Lewis, E.A.  (2007)  "Isothermal Titration Calorimetry: Experimental Design, Data Analysis and Probing Macromolecule/Ligand Binding Interactions", Biophysical Tools for Biologists, ed. Correia, J.J., Detrich, H.W., Academic Press, San Diego, CA, 82, 79-113.
  6. Freyer, M.W., Buscaglia R., Hollingsworth A., Ramos, J.P., Blynn, M., Pratt, R., Wilson, W.D., Lewis, E.A. (2007)  "Break in the Heat Capacity Change at 303 K for Complex Binding of Netropsin to AATT Containing Hairpin DNA Constructs", Biophysical Journal, 92, 2516-2522.
  7. Smith, R.F., Freyer, M.W., Lewis, E.A. (2007) "Biophysical Characterization of Vaccinia Virus Thymidine Kinase Substrate Utilization", Journal of Virological Methods, 142 (1-2), 151-158.
  8. Cashman, D., Buscaglia, R., Freyer, M.W., Dettler, J., Hurley L.H., Lewis E.A. (2008) "Molecular Modeling and Biophysical Analysis of the c-MYC NHE-III1 Silencer Element", J Molecular Modeling, 14(2), 93-101.
  9. Buscaglia, R., Freyer, M.W., Cashman, D., Blynn, M., Hurley, L.H., Lewis, E.A. (2008) "Structural Stability and Porphyrin Binding Interactions of a Mutant Construct of the i-Motif Forming Sequence in the Human c-MYC NHE III1", Biophysical Journal, submitted.