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1. 1. For proving, in 1952, that the genetic material in Escherichia coli and the T₂ bacteriophage was DNA, he/they won the 1969 Nobel Prize:
      1. Frederick Griffith
      2. Watson and Crick
      3. Hershey and Chase
      4. Watson, Crick, and Wilkins
      5. Avery, Macleod, and McCarty

2. 2. These structures are always identical:
      1. Homologous chromosomes
      2. Strands of a DNA double helix
      3. Sister chromatids
      4. Bases belonging to a base pair
      5. None of the above

   3. The most compact form of right-handed, double stranded DNA is:
      1. B-Form DNA
      2. A-Form DNA
      3. Z-Form DNA
      4. H-Form DNA
      5. None of the above

3. 4. DNA is extracted from a cell in Ross Perot's ear and analyzed for nitrogenous base concentration. It is found that 33% of the bases are thymine. What percentage of the bases are guanine?
      1. 67%
      2. 34%
      3. 17%
      4. 0%
      5. Cannot be determined from the information given

   5. DNA is extracted from a cell in Jim Cheaney's scalp. When analyzed for nitrogenous base composition, it was found to contain l8% adenine and 32% guanine. What percentage of the bases in the pre-mRNA transcribed from this DNA are cytosine?
      1. 50%
      2. 32%
      3. 18%
      4. 0%
      5. Cannot be determined from the information given

   6. What percentage of the bases in the pre-mRNA transcribed in problem #5 are thymine?
      1. 50%
      2. 32%
      3. 18%
      4. 0%
      5. Cannot be determined from the information given

4. You have found the DNA sequence that codes for the ability to play "Hail State" on the kazoo while hopping on one leg. The DNA sequence is a follows:
   5' TCA GTT AGA AGC CAT 3'
   7. What is the complementary pre-mRNA sequence?
      1. 5' AGU CAA UCU UCG GUA 3'
      2. 5' UAC CGA AGA UUG ACU 3'
      3. 5' AUG GCU UCU AAC UGA 3'
      4. 5' UCA GUU AGA AGC CAU 3'
      5. 5' ATG GCT TCT AAC TGA 3'

   8. Which DNA-dependent RNA polymerase would produce this pre-mRNA sequence?
      1. I
      2. II
      3. III

   9. What is the amino acid sequence for the appropriate polypeptide that would be synthesized? SEE GENETIC CODE TABLE BELOW.
      1. Ser-Val-Arg-Ser-His
      2. Met-Ser-Leu-Val-Stop
      3. Tyr-Arg-Arg-Leu-Thr
      4. Val-Pro-Trp-Ileu-Lys
      5. Met-Ala-Ser-Asn-Stop

      

   10. Which two amino acids have nondegenerate codons?
       1. gln, lys
       2. met, lys
       3. trp, ser
       4. ser, gln
       5. met, trp

5. 11. The following states that the 5' base of the anticodon and the 3' base of the codon do not pair properly, thus explaining how one tRNA may recognize several codons:
       1. Degeneracy Hypothesis
       2. Crick Theory
       3. Wobble Hypothesis
       4. Mary Lyon Hypothesis
       5. Einstein's Theory of Relativity

   12. Which of the following tRNA anticodons will bind to the following mRNA codon: 5' GGC 3'?
       1. 5' CCG 3' only
       2. 5' GCC 3' only
       3. 5' GCC 3' or 5' ACC 3'
       4. 5' ACC 3' only
       5. 5' CCG 3' or 5' GCC 3'

6. 13. Which of the following required for the initiation of translation in eukaryotes?
       1. 30s ribosomal subunit
       2. IF-1, IF-2, and IF-3
       3. non-formylated methionyl-tRNA
       4. guanosine triphosphate (GTP)
       5. all of the above

   14. Depositing an incoming aminoacyl-tRNA complex into the A-site on the ribosome is accomplished by:
       1. Elongation Factor (Ef-Ts and Ef-Tu)
       2. Peptidyltransferase
       3. Translocation elongation factor (Ef-G)
       4. Aminoacyltransferase
       5. A tiny elf with a magic wand

   15. What is/are the main difference(s) between translation in eukaryotes and prokaryotes?
       1. Methionine instead of N-formyl methionine is translated from one of the initiation codons in prokaryotes.
       2. Transcription and translation are coupled in eukaryotes; they proceed separately in prokaryotes.
       3. Translation occurs on ER-bound ribosomes in prokaryotes, but not eukaryotes
       4. Most eukaryotic mRNAs appear to be monogenic while those of prokaryotes are polygenic.
       5. Two of the above

7. 16. Which of the following enzymes is involved in the separation of the strands of double helical DNA during replication?
       1. helicases
       2. DNA gyrase
       3. DNA single stranded binding protein
       4. All of the above

   17. Which of the following enzymes remove RNA primers on the lagging strand during DNA replication?
       1. DNA Polymerase I
       2. DNA Polymerase II
       3. DNA Polymerase III
       4. All of the above
       5. None of the above

   18. The enzyme responsible for joining Okazaki fragments is:
       1. DNA ligase
       2. DNA polymerase I
       3. Primase
       4. DNA polymerase III

8. A B-form double stranded DNA molecule is 100,000 base pairs long.
   19. How many nucleotides does it contain?
       1. 50,000
       2. 100,000
       3. 200,000
       4. 400,000
       5. None of the above

   20. How long in angstroms is the DNA molecule?
       1. 10,000
       2. 20,000
       3. 40,000
       4. 200,000
       5. None of the above

9. 21. You have discovered a protein with a mass of 300,000 Daltons (1 Dalton = 1 molecular weight unit). If the average amino acid weighs 100 Daltons, how many base pairs (bp) are in the DNA sequence coding for this protein?
       1. 300 bp
       2. 1000 bp
       3. 3000 bp
       4. 9000 bp
       5. 30,000 bp

10. 22. Transcription in prokaryotes is a process that requires key participants for synthesis. Which of the following may serve as a key participant?
        1. RNA primer
        2. deoxyribonucleotide triphosphates
        3. Sigma units
        4. all of the above
        5. none of the above

    23. In eukaryotes, the primary transcripts for tRNAs require further processing. Which of the following statements are false concerning post-transcriptional processing of these RNAs?
        1. some bases are always modified
        2. the sequence CAA is added to the 3' end
        3. there are extra bases added on to the leader sequence (5' end)
        4. all of the above are false
        5. all of the above are true

    24. In eukaryotes, the primary transcript is referred to as heterogenous nuclear RNA (hnRNA) or pre-mRNA, which requires further processing. Which of the following statements are false concerning post-transcriptional processing of pre-mRNA?
        1. A poly A tail is added to the 3' end
        2. A CAP is added to the 5' end
        3. Exons are excised out and introns are joined together to produce the final mRNA product
        4. two of the above
        5. all of the above

11. 25. The following would be classified as a peptide bond:

        1. 

        2. 

        3. 

        4. 

        5. None of the above

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Correct Answers for this Test (question # -- answer)

1 -- C	6 -- D	11 -- C	16 -- D	21 -- D
2 -- C	7 -- C	12 -- C	17 -- A	22 -- C
3 -- B	8 -- B	13 -- E	18 -- A	23 -- C
4 -- C	9 -- E	14 -- A	19 -- C	24 -- C
5 -- E	10 -- E	15 -- D	20 -- E	25 -- B

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